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Microcirculation Research


 

Scientific Publications

Overview

Research

 

Scientific Presentations


Scientific Publications

Overview Articles:

 

Frank, J., Gorantla, V., Barker, JH. Microcirculation research for microsurgeons: Basic concepts and potential applications. Eur J Trauma, 27(4): 153-62, 2001. 

Barker, JH., Anderson, GL., Menger, MD.  Clinically Applied Microcirculation Research.  CRC Press, Inc., Boca Raton, New York, London, Tokyo, 1995. 

Barker, JH., Ryan, T.  Skin Microcirculation. In Clinically Applied Microcirculation Research. (Ed.).  JH. Barker, GL. Anderson, MD. Menger, CRC Press Inc., Boca Raton, New York, London, Tokyo, Chapter 24: 315-337, 1995. 

Barker, JH. Frontiers in Microsurgery: Microcirculation Research (Section editor) 15: 368, 1994

Johnson, P., and Barker, JH.  Thrombosis and antithrombotic therapy in microvascular surgery. (Invited Review) Clinics in Plast Surg.  Vol. 19 No. 4. pp 799-807, 1992. 

Galla, TJ., Barker, JH., Saetzler, RK., Hammersen, F., and Messmer, K. Prevention of skin flap necrosis IN: Ischemic Diseases and the Microcirculation - New Results, (International Symposium, Frankfurt, January 1989). Messmer, K. (Ed). Zuckschwerdt, Munich, Bern, Wien, San Francisco 1989, pp 108-15. 

Messmer, K., Sach, FU., Menger, MD., Bartlett, R., Barker, JH., and Hammersen, F.  Vascular endothelium in health and disease in white cell-endothelium interaction during postischemic reperfusion of skin and skeletal muscle: In Function of Endothelium in Disease, Chien, S. (Ed). Plenum Publishing, Plenum, New York and London, 1988, pp 95-98.

 

Our Research:

Andresen, DM., Barker JH., Hjortdal, VE. Local heparin is superior to systemic heparin in preventing arterial thrombosis. Microsurgery, 22: 265-72, 2002. 

Leukocyte Endothelium Interaction in Arterioles after Ischemia and Reperfusion  J. Surg. Res. 87(1): 77-84, 1999.

F.-W. Peter, D. A. Schuschke, J. H. Barker, B. Fleischer-Peter, J. Hussamnn,  H. U. Steinau: Leukocyte Behavior in a Free Flap Model Following Chemotherapy and Application of Granulocyte Colony-Stimulating Factor (GCSF). Microsurgery 18, 4 (1998) 290-297. 

F.-W. Peter, D. A. Schuschke, J. H. Barker, B. Fleischer-Peter, S. Pierangeli, P. M. Vogt, H. U. Steinau: The Effect of  Severe Burn Injury on Proinflammatory Cytokines and Leukocyte Behavior: Its Modulation with Granulocyte Colony-Stimulating Factor. Burns, 25(6):  477-486 , 1999.

F.-W. Peter, H. U. Steinau, J. H. Barker: Effect of Granulocytes on the Microcirculation in Free Flap Surgery. Langenbeck's Arch. Surg. 383, 5 (1998) 351-354

Peter, FW., Anderson, GL., Gu, JM., Schuschke, DA., Wyllie, F., Acland, RD., Barker, JH.  Do leukocytes contribute to impaired microvascular tissue perfusion after arterial repair? Microsurgery, 18(1): 23-28, 1998.

Barker, JH., van Aalst, V., Keelen, PC., Bidiwala, S., Frank, JM., Carroll, SM., Wan, C., Carroll, CMA., Anderson, GL., Joels, C., Tobin, GR. Vascular delay in skeletal muscle: a model for microcirculatory studies. Plast Reconstr Surg, 100: 665-69, 1997.

F.-W. Peter, D. A. Schuschke, J. H. Barker, H. U. Steinau: Leukocyte Behavior in a Free Flap Model Following Chemotherapy and GCSF-Stimulation. Abstractband, J. Reconstr. Microsurg. ,(1997).

F.-W. Peter, R. J. P. M. Franken, W. Z. Wang, G. L. Anderson, D. A.    Schuschke, M. M. O'Shaughnessy, J. C. Banis, H. U. Steinau, J. H. Barker: Effect of Low Dose Aspirin on Thrombus Formation at Arterial and Venous Microanastomoses and on the Tissue Microcirculation. Plast. Reconstr. Surg, 99(4): 1112-1121, 1997.

F.-W. Peter, R. J. P. M. Franken, W. Z. Wang, J. H. Barker, G. L. Anderson,   D. A. Schuschke, H. U. Steinau: Tissue and Anastomotic Protection in Microvascular Surgery. The Effect of Low Dose Aspirin. Int. J. Microcirc. Clin. Exp., 16 Suppl. 1, 181, (1996).

F.-W. Peter, D.A. Schuschke, J.H. Barker, B. Fleischer-Peter, H.U. Steinau:   The Effect of Severe Injury on the Immune Response. Its Modulation with GCSF. Plastic Surgical Forum 32 , (1996).

F.-W. Peter, J. H. Barker, D. A. Schuschke, B. Fleischer-Peter, H. U. Steinau:  Leukocyte Function and Proinflammatory Cytokines in Severe Burn Injury and its Modulation with Granulocyte Colony Stimulating Factor. Int. J. Microcirc. Clin. Exp., 16 Suppl. 1, 164, (1996).

F.-W. Peter, D.A. Schuschke, J.H. Barker, B. Fleischer-Peter, H.U. Steinau: Leukocyte Function in Severe Burn Injury and its Modulation with Granulocyte Colony Stimulating Factor. Proceedings of the Sixth World Congress for Microcirculation, ISI Publishers, Philadelphia, PA, (1996),  USA. 

F.-W. Peter, R.J.P.M. Franken, W.Z. Wang, G.L. Anderson, D.A., Schuschke, H.U. Steinau, J.H. Barker: Tissue and Anastomotic Protection in Microvascular Surgery. The Effect of Low Dose Aspirin. Proceedings of the Sixth World Congress for Microcirculation, ISI Publishers, Philadelphia, PA, (1996), USA.

Franken RJPM, Peter FW, Anderson GL, Wang WZ, Werker PMN, Schuschke DA, Kon M, Barker JH. Anatomy of the feeding blood vessels of the cremaster muscle in the rat. Microsurgery, 17(7): 402-408, 1996.

Peter, FW., Franken., RJPM, Wang, WZ., Anderson, GL., Schuschke, DH., Steinau, HU., Barker, JH.   Tissue and anastomotic protection in microvascular surgery: the effect of low dose aspirin.  Surg Forum, 47: 744-6, 1996.

Barker JH, Andresen D, Anderson GL, Schuschke D, Gu JM, Hjortdal V, Derr JW, Banis JC, Acland RD.  Can Varying Flow Velocity across an Arterial Anastomosis Prevent Thromboembolic Injury?  Microsurgery, 16: 349-356, 1995.

Andresen, DM., O'Shaughnessy M, Acland RD, Anderson GL, Schuschke D, Banis JC, Barker JH.  Direct visualization and measurement of microsurgically induced thromboembolism. Microsurgery, 15(6): 413-420, 1994.

Frank JM, Kaneko S, Joels C, Tobin GR, Banis JC, Barker JH. Microcirculation research, angiogenesis and microsurgery. Microsurgery, 15(6): 399-404, 1994.

O'Shaughnessy M, Gu JM, Wyllie F, Acland RD, Anderson GL, Banis JC, Barker JH. Microcirculatory consequences of microvascular surgery. Microsurgery, 15(6): 405-412, 1994.

Saetzler RK, Barker JH, Lehr HA, Kamler M, Galla TJ and Messmer K. Visualization of Nutritive Perfusion following Tourniquet Ischemia in Arterial Pattern Skin Flaps: Effect of Vasoactive Medication. Plast Reconstr Surg, 94: 652-660, 1994. 

Uhl E, Barker JH, Bondar I, Galla TJ, Lehr, H, Messmer K.  Improvement of skin flap perfusion by subdermal injection of recombinant human basic fibroblast growth factor.  Ann Plast Surg, 32: 361-366, 1994.  X. W. Liu, F.-W. Peter, J. H. Barker, S. S. Pierangeli, E. N. Harris, G. L. Anderson:

Barker JH, Acland RD, Gu JM, Wyllie F, Anderson GL.  Experimental study of the relationship between alterations in tissue perfusion and anastomotic patency in an experimental free flap.  Microsurgery, 14: 409-415, 1993.

Barker, JH, Gu JM, Anderson GLA, O’Shaughnessy M, Johnson P. Galletti G, Acland RD.  The effects of heparin and dietary cod liver oil on embolicevents in the microcirculation downstream from a small artery repair. Plast Reconstr Surg, 91: 335-343, 1993.

Galla TJ, Satzler RK, Barker JH, Messmer K.  Einsatz vasoaktiver substanzen zur verhinderung von hautnekrosen.  Handchir. Mikrochir. Plast. Chir, 24 1992.

Gu JM, Acland RD, Anderson GL, Barker JH and Wyllie FD.  Poor surgical technique produces more emboli after arterial anastomosis of an island flap.  Brit J Plast Surg, 44: 126-129, 1991. 

Barker JH, Hammersen F, Galla TJ, Bondar I, Zeller P, Menger MD, and Messmer K. Direct monitoring of capillary perfusion following normovolemic hemodilution in an experimental skin flap model. Plast Reconstr Surg, 86: 946-954, 1990.

Barker JH, Hammersen F, Bondar I, Galla TJ, Menger MD, Gross W and Messmer K. Direct monitoring of nutritive blood flow in a failing skin flap; the hairless mouse ear skin flap model.  Plast Reconstr Surg, 84: 303-313, 1989.

Barker JH, Hammersen F, Bondar I, Uhl E, Galla T, Menger M and Messmer K.  The hairless mouse ear for in vivo studies of skin microcirculation.  Plast Reconstr Surg, 83: 948-959, 1989.

Barker JH, Hammersen F, Menger MD, Galla TJ, Bondar I and Messmer K.  Skin ischemia and prevention of reperfusion failure. Prog Appl Microcirculation, 13: 78-92, 1989. 

Barker JH, Menger MD, Sack FU and Messmer K.  Nutritive Hautdurchblutung bei Partieller Ischamie: Wirkung verschiedener vasoaktiver Substanzen. VASA, 17: 37-41, 1988.

Menger MD, Sack FU, Barker JH, Feifel G and Messmer K. Quantitative analysis of microcirculatory disorders after prolonged ischemia in skeletal muscle:  therapeutic effects of prophylactic isovolemic hemodilution.  Res. Exp. Med, 188: 151-165, 1988.

Menger MD, Hammersen F, Barker JH, Feifel G and Messmer K.  Tissue PO2 and functional capillary density in chronically ischemic skeletal muscle.  Adv Exp Med Biol, 222: 631-636, 1987.

 

 

 

Scientific Presentations

Our Work:

X. Liu, FW. Peter, GL. Anderson, S. Pierangeli, JH. Barker: Leukocyte Endothelium Interaction in Arterioles after Ischemia/Reperfusion Plastic Surgery Research Council, 43. Annual Meeting, Loma Linda, CA, April 4-7, 1998.

F-W. Peter, DA. Schuschke, J.H. Barker, P.M. Vogt, HU. Steinau: The Effect of Leukocyte Stimulation with GCSF on Burn Size and Leukocyte Behavior in the Microcirculation. Plastic Surgery Research Council, 42. Annual Meeting, Galveston TX, USA, February 26-March 1, 1997.

F-W. Peter, D.A. Schuschke, JH. Barker, PM. Vogt, HU. Steinau: The Effect of Leukocyte Stimulation with GCSF on Burn Size and Leukocyte Behavior in the Microcirculation. Plastic Surgery Research Council, Galveston TX, USA (1997)

F-W. Peter, DA. Schuschke, JH. Barker, HU. Steinau: Leukocyte Behavior in a Free Flap Model Following Chemotherapy and GCSF-Stimulation. American Society for Reconstructive Microsurgery, 12. Annual Meeting, Boca Raton, FL, USA, January 12-14, 1997 

F-W. Peter, J. Hussmann, HU. Steinau: Aspirin in Micro vascular Surgery. Kleinert, Kutz and Associates Hand Center, Jewish Hospital, University of Louisville School of Medicine, Louisville KY, USA, October 15, 1997.

F-W. Peter, DA. Schuschke, JH. Barker, HU. Steinau: Leukocyte Activation Following Chemotherapy and Reconstructive   Microsurgery. Division of Plastic and Reconstructive Surgery, University of Louisville School of Medicine, Louisville, KY, USA; March 22, 1996.

F-W. Peter, D.A. Schuschke, JH. Barker, JH. Barker, B. Fleischer-Peter, S. Pierangeli, HU. Steinau: The Effect of  Severe Burn Injury on the Immune Response and its Modulation with Granulocyte Colony-Stimulating Factor. Plastic Surgery Research Council, 41. Annual Meeting. St. Louis, MO, USA, June 1- 4, 1996.

F-W. Peter, D.A. Schuschke, JH. Barker, B. Fleischer-Peter, S. Pierangeli, HU. Steinau. The Effect of  Severe Burn Injury on the Immune Response and its Modulation with Granulocyte Colony-Stimulating Factor. Plastic Surgery Research Council, St. Louis, MO (1996).

FW. Peter, JH. Barker, HU. Steinau: Free Tissue Transfer in the Cancer Patient. Department of Plastic Surgery, M. D. Anderson Cancer Center,  University of Texas, Houston, TX, USA; March 27. 1996.

F-W. Peter, JH. Barker, HU. Steinau: The Two Risk Zones in Micro vascular Surgery. Division of Plastic Surgery, University of California at Los Angeles (UCLA), Los Angeles, CA, USA; September 21, 1995.

F-W. Peter, JH. Barker, HU. Steinau: Tissue and Anastomotic Protection in Micro vascular Surgery. Department of Plastic Surgery, M. D. Anderson Cancer Center, University of Texas, Houston, TX, USA; November 8, 1995.

F-W. Peter,  JH. Barker: Aspirin and its Application in Microvascular Surgery. Division of Plastic and Reconstructive Surgery, University of Louisville School of Medicine, Louisville, KY, USA; May 26, 1995.

Keelen, P., Barker, JH., Anderson, GL., Tobin, GR.  Direct visulaization of delay-induced microcirculatory changes in a latissimus dorsi muscle flap model.  Plastic Surgery Research Council Meeting, Ann Arbor, MI, June 4-8, 1994. 

Anderson, GL., Barker, JH., O'Shaughnessy, M., Acland, RD.  Blockade of thromboxane A2 (TXA2) improves capillary perfusion in muscles subjected to platelet emboli.  Presented at the 17th European Conference on Microcirculation, London, UK. July 5-10, 1992.

Barker, JH., Anderson, GL., O'Shaughnessy, M., Pierangel,i S., and Acland, RD.  Embolic injury to the microcirculation in a free flap model is thromboxane A2 (TXA2) mediated. Presented at the 37th Annual Plastic Surgery Research Council Meeting in Toronto, Canada, April 29-May 1, 1992. 

O'Shaughnessy, M., Barker, JH., Anderson, GL., Gu, JM., Acland, RD. The role of thromboxane A2 (TXA2) and vasomotor tone in mediating the adverse effects of platelet emboli on the microcirculation of a free flap model.  Presented at the British Association of Plastic Surgeon's Summer Meeting, Glasgow-UK, July 8-10, 1992.

Acland, RD., Anderson, GL., Barker, JH., Gu, JM., Wyllie, F. Thrombo-embolic events in a free flap model are flow dependent.  Presented at the 36th Annual Meeting of Plastic Surgery Research Council, Charlottesville, VA,  May 5-8, 1991.

Gu, JM., Acland, RD., Anderson, GL., Barker, JH., Derr, JW., O'Shaughnessy, M., White, S. The effects of heparin and dietary fish oil on thrombus/emboli formation and the microcirculation. Presented at the 36th Annual Meeting of Plastic Surgery Research Council, Charlottesville, VA, May 5-8, 1991. 

Gu,  JM., Barker, JH., Anderson, GL., Kim, MK., White, SW., Slater, AD., Pollock, SB., Gray, LA., Tobin, GR.  Vascular anatomy of the latissimus dorsi muscle (LDM).  Presented at the Fifth World Congress for Microcirculation.  Louisville, KY, Aug. 30 - Sept. 5th, 1991.

Kim, MK., Anderson, GL., Barker, JH., Ogden, LL., Uhl, E., White, SW., Tobin, GR. Basic fibroblast growth factor induces angiogenesis in ischemic tissue.  77th Annual meeting of the American College of Surgeons. Chicago, IL, Oct. 20-25, 1991.

Kim, MK., Capowski, JJ., Anderson, GL., Aaronson, K., Barker, JH., Schweitzer, L., White, SW., Tobin, GR.  A computerized semi-automatic tracing system for visualizing and analyzing the 3-D structure of microcirculation.  Presented at the Fifth World Congress for Microcirculation.  Louisville, KY, Aug. 30 - Sept. 5th, 1991. 

Saetzler, RK., Barker, JH., Menger, MD., Messmer, K.  Non-invasive quantification of tissue perfusion:  Comparison of laser Doppler flowmetry and direct intravital fluorescence microscopy in random pattern skin flaps.  Presented at the Fifth World Congress for Microcirculation.  Louisville, KY, Aug. 30 - Sept. 5th, 1991.

Acland, RD., Barker, JH., and Anderson, GL.  The role of emboli in the histopathology of free flap failure.  Presented at the British Society for Reconstructive Microsurgery Meeting. Glasgow, Scotland, January 1990. 

Acland , RD., Barker, JH., and Anderson. GL., Gu,  JM., and Dent, FJ.  Relationship between alterations in tissue perfusion and anastomic patency in an experimental free flap.  Presented at the Plastic Surgery Research Council Meeting, Washington D.C, April 1990.

Galla ,TJ., Barker, JH., and Messmer, K.  Intravitalmikroskopische analysis der mikrozirkulation beim delay-phanamen: Presented at the annual meeting of the German Society for Plastic and Reconstructive Surgery, Tubingen, Germany, October 1990.

Ogden,  LL., Kim, MK., Anderson, GL., Tobin, GR., Acland, RD., Schweitzer, LF., and Barker, JH.  The Effect hypoxia has on growth factor induced neovascularization.  (Poster) Presented at the University of Louisville School of Medicine research day. Louisville, KY, October, 1990.

Acland, RD., Barker, JH., and Anderson, GL.  Direct visualization of thrombli-embolic events in the microcirculation.  Illustrated with living model, Presented at Grand Rounds, Dept. of Surgery, University of Louisville, Louisville, KY, August 1989.

Acland, RD., Barker, JH., and Anderson, GL.  Direct visualization of thrombli-embolic events in the microcirculation.  Illustrated with living model, Presented at Grand Rounds, Dept. of Surgery, University of Louisville, Louisville, KY, August 1989. 

Acland, RD., Barker, JH., and Anderson, GL.  Microcirculatory consequences of vascular Surgery.  Presented to Louisville Hand Surgery, Louisville, KY, August 1989.

Acland, RD., Barker, JH., and Anderson, GL.  Microcirculatory consequences of vascular Surgery. Presented to Louisville Hand Surgery, Louisville, KY, August 1989.

Acland , RD., Barker, JH., and Anderson. GL.  The living microcirculation: Events in a free flap model. Video Presentation at the 5th Annual meeting of the American Society for Reconstructive Microsurgery. Seattle, WA, September 1989.

Acland , RD., Barker, JH., and Anderson. GL. The living microcirculation: Events in a free flap model.  Video Presentation at the 5th Annual meeting of the American Society for Reconstructive Microsurgery. Seattle, WA, September 1989.

Barker, JH., Acland, RD., and Anderson, GL.  A new model for studying thrombus and embolus formation associated with free tissue transfer.  Presented at the American Society of Plastic and Reconstructive Surgeons Meeting, San Francisco, CA, October-November 1989.

Barker, JH., Acland, RD., and Anderson, GL.  A new model for studying thrombus and embolus formation associated with free tissue transfer.  Presented at the American Society of Plastic and Reconstructive Surgeons Meeting, San Francisco, CA, October-November 1989.

Barker, JH., Acland, RD., and Anderson, GL.  A new model for studying thrombus and embolus formation associated with free tissue transfer.  Presented at the 34th Annual Plastic Surgery Research Council Meeting, Atlanta, GA, April 1989. 

Barker, JH., Acland, RD., and Anderson, GL.  A new model for studying thrombus and embolus formation associated with free tissue transfer.  Presented at the 34th Annual Plastic Surgery Research Council Meeting, Atlanta, GA, April 1989. 

Barker, JH., Galla, TJ., Menger, MD., Bondar, I., and Messmer, K.  Direct monitoring of nutritional blood flow in a skin flap following normovolemic hemodilution.  Presented at the 34th Annual Plastic Surgery Research Council Meeting, Atlanta, GA, April 1989.

Barker, JH., Acland, RD., and Anderson, GL.  Microcirculatory consequences of vascular surgery.  Presented to the Department of Surgery. Price Seminar Lecture Series. University of Louisville, Louisville, KY, September 1988.

Wyllie, FJ., Barker, JH., Acland, RD., and Anderson, GL.  The relationship between emboli and blood flow in the microcirculation of a free flap model.  Presented at the Meeting of the British Association of Plastic Surgeons, Bristol, UK, July 1988.

Barker, JH., Hammersen, F.,  Menger, MD., Sack, FU., and Messmer, K.  Drug therapy as a means of enhancing skin flap survival.  Presented at the 4th World Congress for Microcirculation. Tokyo, Japan, July 1987.

Barker, JH., Menger, MD., Sack, FU., and Messmer, K. Normovolemic hemodilutionas a measure for prevention of skin flap survival. Presented at the 4th World Congress for Microcirculation, Tokyo, Japan, July 1987.

 

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